When the vault is too high, the ICL tends to squeeze the peripheral anterior chamber, causing the closure of chamber angle and development of glaucoma ( 1). The vault is the maximum vertical distance from the posterior surface of the ICL to the anterior surface of the lens, and whether ideal vault can be achieved after surgery is an important indicator of the safety of ICL surgery. With the widespread use of ICL implantation, its safety has become a hot topic of clinical concern. Implantable collamer lens (ICL) is an artificial lens implanted into the posterior chamber to correct a patient’s refractive error while preserving the lens itself. The derived formula was found to be superior to the currently available formulas. The study derived a prediction formula for vault by combining ICL size, ATA, and CLR. The 95% agreement limit range of the achieved vault and the vault predicted using the WH formula was narrower than those predicted using the NK and KS formulas (−295.20–258.82 μm).Ĭonclusion: This study combined the results of optical coherence tomography and ultrasound biomicroscopy measurements of the anterior segment of the eye and incorporated ciliary sulcus morphology quantification into the prediction formula. The difference between the achieved vault and that predicted using the WH formula was not statistically significant ( p = 0.165), whereas the difference between the achieved vault and that predicted using the NK and KS formulas was statistically significant ( p < 0.001 and p < 0.001, respectively). The achieved vault 1 month after the surgery was 556.19 μm ± 166.98 μm in the validation group, and the ideal vault range was 200–800 μm (92%). Results: Final ICL size, ATA, CSA, and CLR were included in the prediction formula model (adjusted R 2 = 0.67, p < 0.001). It was validated in 65 patients (118 eyes) to determine the percentage of the ideal postoperative vault range and to compare the differences between the WH formula and the NK, KS, and STAAR formulas. The formula was derived using multiple linear regression analysis and named as WH formula. Vault was measured at 3 months after surgery using CASIA2 anterior segment optical coherence tomography. Various parameters, such as horizontal-visible iris diameter (HVID), photopic pupil diameter (PPD), axial length (AL), white-to-white (WTW), anterior chamber width (ACW), angle-to-angle (ATA), crystalline lens rise (CLR), anterior chamber depth (ACD), horizontal sulcus-to-sulcus (HSTS), and ciliary sulcus angle (CSA) were measured. Methods: Thirty-five patients (61 eyes) with previous posterior chamber intraocular lens implantation were included. The First Affiliated Hospital of Hunan Normal University/ Hunan Provincial People’s Hospital, Changsha, Chinaīackground: To derive and validate a novel vault prediction formula to improve the predictability and safety of implantable collamer lens (ICL) implantation. Hao Wu †, Ding-juan Zhong †, Dong-qiang Luo, Li-yuan Zhang, Jia Liu and Hua Wang *
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